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As gemini ligands induce VDR gem transcriptional activity in mice and normalize their serum calcium levels, VDR gem is a powerful tool to further unravel both liganded and unliganded VDR signaling.
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Moreover, we show that many VDR target genes are repressed by unliganded VDR gem and that mineral ion and bone homeostasis are more impaired in VDR gem mice than in VDR null mice, demonstrating that mutations abolishing VDR ligand binding result in more severe skeletal defects than VDR null mutations.
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New releases: foobar2000 v1.6.12 final - download changes foobar2000 v1.5. On the basis of structure-function correlations, we generated a point-mutated VDR (VDR gem) that is unresponsive to 1,25(OH) 2D 3, but the activity of which is efficiently induced by the gemini ligands. foobar2000 v2.0 beta: download read change log foobar2000 for Mac v2.5 beta: download read change log. The 3D structures of the VDR ligand-binding domain with 1,25(OH) 2D 3 or gemini analogs unveiled the molecular mechanism underlying ligand recognition. Download the Geminit 12 client versions of Titan for Mac and Windows and updates for your computers quickly and easily from this page. The bioactive form of vitamin D regulates mineral and bone homeostasis and exerts potent anti-inflammatory and antiproliferative properties through binding to the vitamin D receptor (VDR).
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